Abstracts
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Talk Abstracts (Scroll down for poster abstracts)
Poster Abstracts
| Poster No. | Authors | Title |
| BIOMATERIALS | ||
| P1 | Kavya Anjur1, Eric Roth2, Vinayak P. Dravid, Ph.D3 | Optimizing Freezing and Etching Parameters of CryoSEM Analysis of Hydrogels for Biomedical Applications |
| P2 | Hadi Hezaveh1,2, Luis Malaver, Steffen Cosson, Ellen Otte, Guannan Su, Justin Cooper-White1,2,3 | Encoding cellular ECM microenvironments with dynamically remodelling synthetic hydrogels |
| P3 | Leila Daneshmandi1, 2, Cato T. Laurencin1,2,3 | PLGA/CaO2 Matrices for Enhanced Bone Regeneration In Vivo |
| P4 | Luo Gu1,2, Alex Najibi2, Maxence Dellacherie2, Ting-Yu Shih2, Aileen Li2, and David Mooney2 | Biomaterial Immune Niches for Generating Strong and Persistent Humoral Immune Responses |
| P5 | Wei Li | Nanostructured Biodegradable multilayered films for cell isolation and recovery |
| P6 | Kathleen L. Miller1#, Claire Yu, Ph.D.1#, Jacob Schimelman1, Shaochen Chen, Ph.D.1 | Rapid 3D Bioprinting of Gelatin Hydrogels via Click Chemistry |
| P7 | Settimio Pacelli, Ph.D.1, Kyle Rampetsreiter1, Saman Modaresi1, Siddharth Subham1, Aparna R. Chakravarti, Stefan Lohfeld, Ph.D.2, Michael S. Detamore, Ph.D.3, Arghya Paul, Ph.D.1 |
Double crosslinked interpenetrating polymeric network hydrogel treated with polydopamine to modulate adipose stem cell osteogenic differentiation |
| P8 | Courtney Gegg1, Xinming Tong2, Fan Yang1,2 | Microribbon-based Hydrogels with Tunable Compositions as 3D Stem Cell Niche Restored Cartilage Mechanical Strength |
| EXTRACELLULAR MATRIX | ||
| P9 | Abdolrasol Rahimi, M.S.1, Kara Tsuzaki, M.S.1, Logan Verheyen1, Scott Sell, Ph.D1 Natasha Case, Ph.D1 |
Enhancing Collagen Deposition in Electrospun Silk Scaffolds by a Macromolecular Crowding Approach |
| P10 | Cody Crosby, M.S.E.1, Deepti Valliappan1, David Shu1, Chengyi Tu, Ph.D1, Janet Zoldan, Ph.D1 | Cell-Matrix Interactions Regulate the Vasculogenic Potential of iPSC Derived Endothelial Progenitors in Collagen Hydrogels |
| P11 | Aidan Gilchrist1, Brendan Harley1 | MSC-secreted factors within a gelatin-based bone marrow mimetic |
| P12 | Karina H. Nakayama, PhD1,2,3, Cynthia Alcazar, BS1, Marco Quarta, PhD 1,4, Thomas A. Rando, MD, PhD,1,4, Ngan F. Huang1,2,3 |
Transplantation of Spatially Patterned Nanofibrillar Scaffolds and Rehabilitative Exercise Enhance Vascularization and Innervation Following Volumetric Muscle Loss |
| P13 | Adam Jorgensen1, Zack Chou2, Shay Soker1, Anthony Atala1 | Decellularized Human Skin-Derived ECM Improves Fibroblast Proliferation and Viability in 3D Fibrin Hydrogel Constructs |
| P14 | Kristopher E. Kubow, Ph.D., Michael Pamonag, Nojan Jafari, Dominic J. Sales, Victoria D. Shuklis, Abigail Hinson, and Elisha Burton |
Ability of individual cells to remodel substrate fibers guides protrusion direction, cell polarization, and migration persistence |
| P15 | Martin T. Spang, M.S.1, Gerardo Sandoval1, Tori S. Lazerson1, Colin Luo1, Kent Osborn, D.V.M, Ph.D.1, Pedro Cabrales, Ph.D.1, Francisco Contijoch, Ph.D.1, Ryan R. Reeves, M.D.1, Anthony N. DeMaria, M.D.1, Karen L. Christman, Ph.D.1 |
A pro-regenerative extracellular matrix hydrogel therapy for acute myocardial infarction |
| P16 | Alice E. Stanton,1 Xinming Tong,2 and Fan Yang1,2 | Elucidating the Effects of Varying Ligand Type on Mechanotransduction of Mesenchymal Stem Cells using Hydrogels with Enhanced Conjugation Efficiency |
| P17 | Weikun Xiao, Alireza Sohrabi, Arshia Ehsanipour, Jesse Liang, and Stephanie K. Seidlits | Brain-mimetic Hydrogel Platform to Study Glioblastoma Oncology |
| P18 | Janet Zoldan | Matrix Anisotropy in Cardiac Differentiation and Cell Sheeting |
| BIOMECHANICS | ||
| P19 | Jessica Aldrich1, David Long, Ph.D.1 | Effects of Fluid Shear Stress on Chromatin Organization |
| * P20 | Salma Ayoub, Ph.D. 1, Jordan Graves1, Chung-Hao Lee, Ph.D. 2, Michael S. Sacks, Ph.D.1 | A Physiologically-Driven Biaxial Bioreactor System to Investigate Valve Interstitial CellPhenotypic State after Surgical Repair |
| P21 | William Bachman and David S. Long, PhD. | Modeling Framework to Quantify the Force Transmission in Endothelial CellClusters: A Cluster-Specific Model and Virtual Multi-Cell Model |
| P22 | Pranjali Beri1, Anna Popravko1, Alyssa Chiang1, Jesse Placone1, Afsheen Banisadr2, Adam Engler1 | Metastatic Potential of Breast Cancer Cells is Indicated by Adhesion Strength |
| P23 | Christina Conrad1, Kelsey M. Gray1, Kimberly M. Stroka, Ph.D.1,Imran Rizvi, Ph.D.2, Giuliano Scarcelli, Ph.D.1 | Mechanical Characterization of 3D Ovarian Cancer Tumor Nodules using Brillouin Confocal Microscopy |
| P24 | Yuntao Xia1,2, Irena Ivanovska1,2 and Dennis E. Discher1-2 | Nuclear rupture at sites of high curvature compromises retention of DNA repair factors |
| P25 | S. Omid Komari, Ph.D.1, Ryan M. Musselman1, Adam P. Klausner, M.D. 1,John E. Speich, Ph.D.1 | Actin-Myosin Interaction Model for Length Adaptation in Bladder Smooth Muscle |
| P26 | Stephen Lenzini, M.S., Jae-Won Shin, PhD | Biophysical interactions regulate extracellular vesicle prod |
| P27 | 1,2,4,5 Deborah Leckband, Ph.D., 2Zainab Rahil, Ph.D., 4Vinh Vu, 3Ellen Qin, 1,5Hyun-Joon Kong, Ph.D. |
Is Intercellular Force Transduction a Combinatorial Switch? |
| P28 | Xinyu Kong 1, Arkaprava Dan, Ph.D.2, Deborah Leckband, Ph.D.1,2 | Mechanisms Regulating Endothelial Barrier Permeability During Cyclic Stretch |
| P29 | Saman Modaresi 1, Settimio Pacelli1, Jonathan Whitlow1, Arghya Paul1 | Investigating the Role of Substrate Stiffness on Stem Cell Transfection Using LipidBased Nanocarriers to Deliver Angiogenic genes |
| P30 | Pankaj Mogha*2, Ankita Srivastava*1, Sreya Das1, Sushant Kumar1, Sanjay Kureel2, Alka Dwivedi1, Atharva Karulkar1, Ankit Gupta3 , Chitra Nayak3, Abhijit Majumder#2, Rahul Purwar#1 |
Soft substrate boosts proliferative potential and maintains keratinocytes functionality duringin-vitro expansion compared to plastic. |
| P31 | Sara Hopper2, Kayla Barton1, Tayler Laycox1, Ella Bonfield1, Jason W. Nichol PhD1,2 | Elucidating response to changes in mechanical environment in stem and cancer cells |
| P32 | Thomas Petet1, Halston Deal1, Arianna DeCastro1, Christina Tang, Ph.D1, Seth Weinberg, Ph.D.1, Christopher Lemmon, Ph.D.1 |
Substrate Viscosity Dictates Cellular Response |
| P33 | Ramesh Koirala 1,2, Andrew V. Priest 1.2, Sanjeevi Sivasankar 1 | Mechanosensitive cadherin adhesion and its regulation |
| P34 | Omer Shafraz 1,2, Matthias Rübsam 3, Sara N. Stahley 4, Amber Caldara 4, Andrew P. Kowalczyk 4, Carien M. Niessen3, Sanjeevi Sivasankar 1.2 |
E-cadherin Binds to Desmoglein to Facilitate Desmosome Assembly |
| P35 | Catalina-Paula Spatarelu1*, Dung Trung Nguyen1,2*, Calin Mocanu3, Zi Chen1 | Modelling Cell Monolayers During Jamming/Unjamming Events |
| P36 | Robert Tranquillo, Victor Lai, Victor Barocas, Rohit Dhume and Lauren Bersie | A Computational Microstructural Model of Cell Contact Guidance in Aligned Fibril Networks |
| P37 | Kai Wang1, Lin Shi2, Yong Yang1* | Time-Stiffness Superposition of Carbon Nanotubes-induced Fibrogenesis |
| P38 | Yi-Ting Yeh1,2, Danielle E. Skinner3, Brian M. Suzuki3, Shun Zhang1, Youjeong Na3, James H. McKerrow3, Juan C. del Alamo1,2 * and Conor R. Caffrey3 * | Biomechanical interactions of Schistosoma mansoni eggs with vascular endothelial cells |
| MOLECULAR AND CELLULAR ENGINEERING | ||
| P39 | Kavya Anjur 1 , Lakshmi Rajagopal, Ph.D. 2 , Herbert Y. Meltzer, Ph.D 3 | Pharmacological Effects of Clozapine on GABAergic Systems and Related Secondary Structural Changes in 5-HT 2C R, of Significance to Amyotrophic Lateral Sclerosis and Cognitive Deficits in Schizophrenia |
| P40 | Jenette G. Creso1, Jeffrey R. Moore2 & Stuart G. Campbell1 | Evaluating Pathogenicity of Cardiac Thin Filament Proteins Using Adenoviral Transduction of Engineered Heart Tissue |
| P41 | Aditya Kumar1, Stephanie Thomas1, Kirsten Wong1, Valentina Lo Sardo2, Daniel Cheah1, Yang-Hsun Hou1, Jesse Placone1, Kevin Tenerelli1, William Ferguson2, Ali Torkamani2,3, Eric Topol3, Kristin Baldwin2, Adam Engler1,4 | Non-Coding Genomic Regulation Identified in Human Cardiomyocytes |
| P42 | J.A. Garcia, D. Ramos-Pérez, D.F. Vázquez, D.L. Alejandro, D. Carballo-Rodríguez, B.A. Irizarry, and M.J. Bayro | HIV-1 Gag Protein Nanoparticle Systems: Assembly and Viral Inhibition Strategies |
| P43 | Daniel P. Howsmon, Ph.D.1 and Michael S. Sacks, Ph.D1 | Mathematical Modeling of Cellular Networks Regulating Extracellular Matrix Synthesis and Actin Dynamics in Valvular Interstitial Cells |
| P44 | Ziliang Huang1, Yiqian, Wu1, Molly Allen1, Yijia Pan1, Phillip Kyriakakis1, Shaoying Lu1, Ya-Ju Chang1, Xin Wang1, Shu Chien1,2, and Yingxiao Wang1,2* | A light-inducible gene activation system toward controllable cell-based therapeutics |
| P45 | 1Swatabdi R. Kamal, 1Shreya Potukutchi, 1Maxwell T. Laws, 2 Ana DeCarvalho, Ph.D., and 1Juri G. Gelovani, M.D., Ph.D. | HDAC4 as target for epigenetic imaging and therapy of glioblastomas. |
| P46 | Woo Lee, Ph.D.1 and Jenny Zilberberg, Ph.D.2 | Engineered Bone Niche of Incurable Cancers |
| P47 | Quang Long Pham, Ph.D.1, Lydia N. Rodrigues,1 Max A. Maximov,1 Vishnu Deep Chandran,1 Cheng Bi,1 David Chege,2 Timothy Dijamco,3 Elisabeth Stein,1 Nhat Anh Nguyen Tong,1 Sagnik Basuray, Ph.D.1, and Roman S. Voronov, Ph.D.1 | Image-Based Modeling of Fibroblasts Modifying PDGF-BB Gradient Explains Cells’ Alternated Directional Decision during Chemotaxis in a Microfluidic Maze |
| P48 | Quang Long Pham, Ph.D.1, Lydia N. Rodrigues,1 Max A. Maximov,1 Vishnu Deep Chandran,1 Cheng Bi,1 David Chege,2 Timothy Dijamco,3 Elisabeth Stein,1 Nhat Anh Nguyen Tong,1 Sagnik Basuray, Ph.D.1, and Roman S. Voronov, Ph.D.1 | Cell Sequence and Mitosis Affect Fibroblast Directional Decision-Making during Chemotaxis in Tissue-mimicking Microfluidic Mazes |
| P49 | Virali Parekh1, Roshan Thakuri1, Janelle Fried2, Erica Everson1, Kyden DeGross1, Ary Marsee3, Mark Novak, Ph.D.1, Richard Sinden, Ph.D.1 | Targeted Deletion of Expanded (GAA)n Repeats in Friedreich Ataxia using Triplex DNA Binding Agents |
| STEM CELL ENGINEERING | ||
| P50 | Aparna R. Chakravarti1, Settimio Pacelli, Ph.D.1, Perwez Alam, Ph.D. 2, Samik Bagchi, Ph.D.3, Saman Modaresi1, Andras Czirok, Ph.D. 4, Rafeeq P.H. Ahmed, Ph.D. 2, Arghya Paul, Ph.D. *1 | Fabrication of a biomimetic environment to pre-condition stem cells for enhanced cardiac tissue repair |
| P51 | Nathan Cho1, Megan L. Rexius-Hall, Ph.D.1, Joycelyn K. Yip1, Megan L. McCain, Ph.D1 | Engineering Spatial Alignment of Human Induced Pluripotent Stem Cells to Promote Cardiac Myocyte Differentiation |
| P52 | Taekyung Lee, M.S.1, Sungki Min, Ph.D.2, Junghwa Hong, Ph.D.1 | Endogenous Electricity on Trabecular Surface of Intertrabecular Pore, in situ MSC Niche |
| P53 | Ruoxing Lei1,2, Kelly C. Y. Wong2, Kayla Wolf2,3, Sanjay Kumar, M.D., Ph.D.2,3,4 | A High-throughput Hydrogel Array Platform for Investigating Stem Cell Mechanobiology |
| P54 | Yuguo Lei, Ph.D.1, Qiang Li, M.S.1, Haishuang Lin, Ph.D1 | Scalable and Physiologically Relevant Microenvironments for Human Pluripotent Stem Cell Expansion and Differentiation |
| P55 | Rita Matta, M.S. *1, Seyong Lee, Ph.D. *2,3, Jean-Leon Thomas, Ph.D. 2,3,4, and Anjelica L. Gonzalez, Ph.D.1 | Minimally Invasive Delivery of Microbeads with Encapsulated, Viable and Quiescent Neural Stem Cells to the Adult Subventricular Zone |
| P56 | Kaivalya Molugu1,2, Ty Harkness1,3, Jared Carlson-Stevermer1,3, Tiffany Heaster1,3, Ryan Prestil1, Stephanie Seymour1, Gavin Knight1,3, Randolph Ashton1,3, Melissa Skala1,2,3, Krishanu Saha1,2,3 | Micropatterned substrates for dissecting heterogeneity in reprogramming human somatic cells |
| P57 | Brett N. Napiwocki, M.S., Di Lang, Ph.D., Ravi Vaidyanathan, Ph.D., Jianhua Zhang, Ph.D., Ph.D., Jonathan C. Makielski, M.D., Lee Eckhardt, M.D., Alexey Glukhov, Ph.D., Timothy J. Kamp, M.D., Ph.D., Wendy C. Crone, Ph.D. |
Anisotropic Cardiac Tissues Inspired by the Myocardial Microenvironment |
| P58 | Olivia J. Scheideler1, David V. Schaffer, Ph.D.1, Lydia L. Sohn, Ph.D.1 | A High-Throughput Approach for Assembling Multiplexed DNA Patterns to Recapitulate Niche Signaling Interactions with Spatiotemporal Control |
| P59 | Hao Zhou1, Lisa Nguyen, Ph.D.2, Cosimo Arnesano, Ph.D.3,4, Yuta Ando1, Scott Fraser, Ph.D.1,2,3,4, Rong Lu, Ph.D.1,2,5, Keyue Shen, Ph.D.1,2,5 | Distinguishing Hematopoietic Stem and Progenitor Cells with NADH Profiles |
| P60 | Alana Stempien1, Jonathan J. Hernandez 2, Jacob Notbohm1, Wendy C. Crone1 | Evaluating Structure and Mechanical Function in CPVT Stem Cell Derived Cardiomyocytes |
| P61 | Bailey Winter, Sam Daniels, Joseph Salatino, Kylie Smith, Steve Suhr and Erin Purcell | Direct conversion of astrocytes into functional neurons using Ascl1 and Dlx2 |
| DEVELOPMENT AND MORPHOGENESIS | ||
| P62 | Stephanie I. Fraley, Ph.D | 3D confinement regulates cell adhesion, metabolic stress, and collective morphogenesis |
| P63 | Rachel M Gilbert, Jason P. Gleghorn | Embryonic lung mesothelium regulates of airway branching morphogenesis via tissue crosstalk |
| P64 | Brielle Hayward-Piatkovskyi1, Jasmine Shirazi2, Saurabh Modi2, Sienna C. Pyle2, Jason P. Gleghorn1,2 | Pulmonary vascular morphogenesis is dependent on sex-based differences |
| P65 | Sarah Grundeen1, Luke Theogarajan, Ph.D.1, Adele Doyle, Ph.D.1 | Exploiting surface acoustic waves to study development of stem cell-derived motor neurons |
| ORGANOIDS | ||
| P66 | Kavya Anjur1, Peter Andersen, Ph.D.2, Chulan Kwon, Ph.D2 | Heart fields are induced by coordinated activities of Wnt/Bmp signals in pre-cardiac organoids |
| P67 | Alyssa Fasciano1, Shumin Tan, Ph.D.2, and Joan Mecsas, Ph.D.1,2 | Investigating host-pathogen interactions of Yersinia pseudotuberculosis in the intestine using ileum enteroid-derived monolayers |
| P68 | LeeAnn Li1,2, Danny Wen-Chin Huang1, Xili Ding1, Yuan-Yu Hsueh1, Song Li1 | Engineering Stem Cell Spheroids to Rescue Muscular Denervation Atrophy |
| P69 | Jiwon Kim, M.S.1, Youngbin Cho, M.S.1, Unghyun Ko, Ph.D.1, Jennifer H. Shin, Ph.D.1 | Evaluation of spheroidal cancer models based on invasion phenotype |
| P70 | Alireza Sohrabi1, Weikun Xiao1, Jesse Liang1, Arshia Ehsanipour1, Deepthi Muthukrishnan2, Harley Kornblum2,3,4,5, Stephanie Seidlits1,3,4,5 | Role of Tumor Microenvironment Biophysical Properties on Glioblastoma Progression |
| ORGAN ON A CHIP | ||
| P71 | Hesam Babahosseini, Ph.D.1,2, Tom Misteli, Ph.D.1, Don L. DeVoe, Ph.D2 | On-chip High-throughput Droplet Generation, Storage, and Retrieval |
| P72 | Geneva R. Doak, B.S., Kathryn L. Schwertfeger, Ph.D., David K. Wood, Ph.D. | Microfluidic Model to Investigate Macrophage Roles in Breast Cancer Cell Extravastion |
| P73 | Drew Glaser1, Natalie Ng2, Leif Anderson1, Aravind Anand1, Alyssa Deely1, Priscilla Hwang3, Nuala Del Piccolo1, Venktesh Shirure1, Daniel Link3, Katherine Weilbaecher3, Steven George1 | A Microfluidic Approach to Create Endosteal and Perivascular Bone Marrow Niches |
| P74 | Matthew Ishahak, MS1, Jordan Hill1, Victoria Graham, BS1, Alexis Sloan, Ph.D. 1, Alessia Fornoni, M.D., Ph.D.1, Ashutosh Agarwal, Ph.D.1 | Engineering a Micropysiological Model of the Glomerulus |
| P75 | WonJin Kim1, JaeYoon Lee1, Miji Yeo1, JiUn Lee1, HaeRi Kim1, JuYeon Kim1 and Geun Hyung Kim1* | 3D cell-laden collagen intestinal model mimicking intestinal villus epithelium and capillary network for intestine-on-a-chip |
| P76 | JiUn Lee1, WonJin Kim1, Minseong Kim1, Gi Hoon Yang1, YoungWon Koo1, YoungEun Choe1, Soo Jung Chae1, GeunHyung Kim1* |
Development of a new 3D printing process to fabricate ECM mimic 3D fibrous collagen scaffold and bone model for organ-on-a-chip |
| P77 | Shiny Rajan1,2, Andrea Mazzocchi1,2, Konstantinos Votanopoulos3,4, Aleksandar Skardal1,2,4, and Adam Hall1,2,4 | Tumor-on-a-chip microfluidic devices for personalized cancer drug testing |
| P78 | Shiny Rajan1, 2, Sean Murphy1, 2, and Adam Hall1, 2, 3 | An adhesive film-based lung-on-a-chip system to test environmental pollutants and drugs |
| P79 | Whitney Sinclair1, Cathy Murphy, Ph.D.2, Deborah Leckband, Ph.D.1,2,3, Paul Kenis, Ph.D.1,3 | Efficient Fabrication of Lung-on-a-Chip Device with in situ Imaging Capability |
| P80 | Armin Tahmasbi Rad1,2, Wafa Aresh, Ph.D. 1, Mu-Ping Nieh, Ph.D.1,2,3 | A Tumor-on-a-Chip Strategy to Examine the Impact of the Design of Lipid Nanoparticles on their Transportation into 3D Ovarian Tumor |
| P81 | Gulistan Tansik, Ph.D.1,2,3, Ahmad Alassaf1, Diana Velluto, Ph.D.4, Rajeev Prabhakar, Ph.D.5, Ashutosh Agarwal, Ph.D.1,2,3,4 | Cardiac Amyloidosis on a Chip |
| P82 | Joycelyn K. Yip1, Michael Harrison, PhD2, Ching-Ling (Ellen) Lien, PhD1,2, Megan L. McCain, PhD1 | Fluidic Device for Long-Term Culture and Imaging of Explanted Zebrafish Hearts |