Abstracts



Talk Abstracts (Scroll down for poster abstracts)
Talk No. Authors Title
Keynotes
T1 Cato Laurencin Regenerative Engineering, A New Convergence Field
T2 Melody Swartz Lymphatic vessels in the tumor microenvironment: How active transport mechanisms regulate local immunity
T3 Farshid Guilak Deconstructing mechanotransduction to identify targets for mechanobiologic therapies
T4 Dennis Discher Scaling concepts and mechanisms in matrix mechanobiology: from differentiation to cancer
T5 Molly Stevens Exploring and Engineering the Cell-Material Interface for Regenerative Medicine and Mechanobiology
T6 Todd McDevitt Engineering the Self-directed Multicellular Organization of Human Pluripotent Stem Cell Systems
Faculty Presentations
T7 Leo Wan Cellular Left-Right Asymmetry in Development and Disease
T8 Celeste Nelson Forced understanding of tissue morphogenesis
T9 Shelly Peyton Tissue Guided Hydrogel Design
T10 Bianxiao Cui Membrane curvature at the nano-bio interface
T11 Cynthia Reinhart-King Metastatic cell migration through complex microenvironments
T12 Todd Sulchek Microfluidic Cell Sorting by Biophysical Properties to Examine Heterogenic States of Cells
T13 Andrea Tan, Sofia Barbosa and Clark Hung Modulation of Cell-to-Cell Variability for Functional Tissue Engineering of Cartilage
T14 Pamela Kreeger Heterogeneity in ovarian cancer – is the microenvironment a viable target?
T15 Delphine Dean Cardiac Cell Heterogeneity and Mechanical Properties
T16 Dawn Elliott, Andrea Lee and Babak Safa Microscale structure, mechanics, and damage of tendon
T17 Guy Genin Mechanobiology of proteoglycan-like molecules at the plant cell periphery
T18 Robert Mauck Reprogramming cell and ECM physical properties to promote dense connective tissue repair
T19 Christopher Chen Mechanoregulation of vascular function by the Notch receptor
T20 Kris Dahl Measuring intracellular force and chromatin condensation by tracking sub-nuclear sensors
T21 Weiyi Qian, Zijing Zhang, Joyce Yan, Kevin Guang, Apratim Bajpai and Weiqiang Chen Mechano-modulation of Cancer Stem Cells through Endogenous Traction-imbalance
T22 Robert Tranquillo Fibroblast contact guidance in aligned fibrin fibril networks  via sensing of stiffness anisotropy
T23 Amit Pathak Mechanical Memory in Collective Cell Migration
T24 Guohao Dai Nrp1 Mediated Arterial Differentiation of Pluripotent Stem Cells
Rising Star Awards
T25 Bin Li, Weiyu Zhao, Xiao Luo, Xinfu Zhang, Chenglong Li, Chunxi Zeng and Yizhou Dong Engineering CRISPR/Cpf1 to maximize genome editing efficiency
T26 Akhilesh Gaharwar Widespread Changes in Transcriptome Profile of Human Mesenchymal Stem Cells by Two-Dimensional (2D) Nanosilicates
T27 Liming Bian Self-assembled Injectable Nanocomposite Hydrogels Stabilized by Bisphosphonate-Magnesium (Mg2+) Coordination Regulates the Differentiation of Encapsulated Stem Cells via Tunable Mechanosensitive Network Structure
T28 Daniel Conway and Vani Narayanan Mechanical force across E-Cadherin regulates epithelial acini homeostasis
T29 Julian Hassinger, David Drubin and Padmini Rangamani Membrane tension as an organizing principle for vesicle trafficking
T30 Cody Narciso, Qinfeng Wu, Pavel Brodskiy, Ali Nematbakhsh, Jamison Jangula, Dharsan Soundarrajan, Megan Levis, Francisco Huizar, Peixian Liang, Nicholas Contento, David Hoelzle, Danny Z. Chen, Mark Alber and Jeremiah J. Zartman Mechanical stress dissipation during organ growth through calcium signaling
T31 Sarah Calve, Andrea Acuna and Craig Goergen MEASUREMENT OF HETEROGENEOUS EXTRACELLULAR MATRIX FIBRIL DEFORMATION IN SITU
T32 Omar Banda, Ryan Taitano and John Slater A New Traction Force Microscopy Platform Containing a Built-In Zero-Stress State
Post Doctoral Awards
T33 Yue Shao, Kenichiro Taniguchi, Katherine Gurdziel, Ryan Townshend, Xufeng Xue, Koh Meng Aw Yong, Jianming Sang, Jason Spence, Toshio Miki, Deborah Gumucio and Jianping Fu Bioengineered in vitro Model for Post-implantation Human Embryogenesis
T34 Sangpil Yoon, Kirk Shung and Yingxiao Wang hPiezo1 Needs Stronger Force for Mechanical Activation than mPiezo1
T35 Claire Robertson, Ariel Kent, Nasima Mayer, Camilla Hochman-Mendez and Mina Bissell Laminin microstructure compensates for dystroglycan loss in breast epithelial cells
T36 Kaitlin Fogg and Pamela Kreeger Alternatively Activated Macrophage-Derived HB-EGF and Extracellular Matrix Stiffening Promote the Expansion of Ovarian Cancer Spheroids
T37 Edward Bonnevie, Tonia Tsinman, Sarah Gullbrand, Dawn Elliott and Robert Mauck Prestrain Regulates Mechanosensation in Fibrous Microenvironments
Graduate Student Awards
T38 Yash Shah, Lorena Maldonado-Camargo, Neal Patel, Adam Biedrzycki, Elena Yarmola, Jon Dobson, Carlos Rinaldi and Kyle Allen Magnetic particle translation as a surrogate measure for synovial fluid mechanics
T39 Kelsey Gray, Sukriti Ghosh and Kimberly Stroka Electrodeposition of PEG-Hyaluronan-Gelatin Hydrogels to  Spatiotemporally Control Cell Matrices for Mechanobiological Study
T40 Tugba Topal, Cheri Deng and Paul Krebsbach Acoustic Tweezer Induced Cyclic Forces Mediate Rapid Epithelial-Mesenchymal Transition in Human Embryonic Stem Cells
T41 Junghyun Kim, Brian Li, Kristen Cotner, Sewoon Han and Lydia Sohn Multi-Variable Mechanical Phenotyping with Mechano-Node-Pore Sensing
T42 Milos Spasic, Quincy Delp and Christopher Jacobs Drug screening of primary cilia-targeted therapies for in vivo osteoporosis treatment
T43 Rachel Gilbert and Jason Gleghorn Developmental mechanotransduction: The role of epithelial stretch on local growth factor secretion during lung airway morphogenesis
T44 Anastasia Korolj, Carol Laschinger, Christian James, Erding Hu, Robert Willette, Claire Velikonja, Nathaniel Smith, Samad Ahadian, Milica Radisic and Boyang Zhang Microcurvature promotes podocyte differentiation in vitro


Poster Abstracts
Poster No. Authors Title
P1 Nasya Sturdivant, Hector Rosas-Hernandez, Syed Ali and Kartik Balachandran Characterization of blood-brain barrier breakdown in an in vitro stretch model and in vivo closed-head injury model of mild to moderate traumatic brain injury
P2 Marina Shumakovich, Gregory Dawson and Kimberly Stroka Engineered Hyaluronic Acid Matrices for Studying Unique Mechanobiology of Tumor Metastasis Across the Blood-Brain Barrier
P3 Michelle Dawson, Deepraj Ghosh and Botai Xuan Biophysics of Giant Polyploidal Cancer Cells that Form in an Aging Tumor Stroma
P4 Amina Mohammadalipour, Monica Burdick and David Tees Biomechanical phenotype of breast cancer stem cells
P5 Karin Wang and Jeffrey Fredberg Reshaping the breast tumor boundary by initiating collective migration  in a model system
P6 Andy Fleszar, Darian James, Alyssa Walker, Paul Weisman, Paul Campagnola and Pamela Kreeger The physical properties of ovarian cortical inclusion cysts promote fallopian tube epithelial cell invasion
P7 Michael Mitchell Disrupting Physical Interactions Between Multiple Myeloma and the Bone Marrow Niche In Vivo via Nanoparticle-Mediated RNAi
P8 Nabiollah Kamyabi and Siva Vanapalli Cancer cells survive mechanical fragmentation under microcirculatory conditions
* P9 Isabelle Stasenko, Efraín Cermeño and Andrés García Breast Cancer Cell Adhesive Properties and Correlation to Tumor Initiating Cell (TIC) Phenotype
P10 Hydari Begum, Kristen Nemes and Keyue Shen Understanding Metabolic Reprogramming at the Tumor-Stromal Interface In Vitro
P11 Rebecca Moriarty and Kimberly Stroka Effect of mechanical confinement on sarcoma cell cycle progression
P12 Yamicia Connor, Yonatan Tekleab, Sarah Tekleab, Shyama Nandakumar, Divya Bharat and Shiladitya Sengupta A 3D Co-Culture Model of Tumor-Endothelial Interaction
P13 Andres Rubiano, Song Han, Steven Hughes and Chelsey Simmons Stromal Remodeling Protects Pancreatic Cancer Cells from Chemotherapy in 3D Microtissues
P14 Isaac Adjei, Madison Temples, Julie Djeu and Blanka Sharma Engineering Tumor Microenvironments to Investigate Natural Killer Cell-Cancer Cell Interactions
P15 Manisha Shah, Elizabeth Leary, Jeffrey Morgan and Eric Darling Incorporation of Cell Mimicking Microparticles into a 3D Tumor Model of Melanoma
P16 Zhen Ma, Nathaniel Huebsch, Bruce Conklin, Costas Grigoropolous and Kevin Healy Biomechanics-guided disease modeling of human familial cardiomyopathy
P17 Jesse Rogers, Angela Zeigler, Jeffrey Saucerman, Jeffrey Holmes and William Richardson Fibroblast Systems Mechanobiology Model Predicts Mechano-Adaptive Infarct Therapies
P18 Lauren Baugh, Phil Hinds, Gordon Huggins and Lauren Black CD44 Signaling Promotes Mineralization in an in Vitro Model of CAVD
P19 Hanna Sanyour, Josh Childs, Na Li, Alex Rickel and Zhongkui Hong Does Membrane Cholesterol Regulate the Biomechanics and Migration of Vascular Smooth Muscle Cell Substrate Stiffness Dependently?
* P20 Ishita Tandon, Olivia Kolenc, Kyle Quinn and Kartik Balachandran Label-Free Metabolic Imaging to Assess Calcific Aortic Valve Disease Progression
P21 Katelyn Reece and David Long Imaging the Glycocalyx on Human Microvascular Endothelial Cells (HMEC-1) 
P22 Jessica Perez, Ishita Tandon and Kartik Balachandran Role of Local Renin-Angiotensin System in Altering Aortic Valve  Function and Remodeling
P23 Debanjan Mukherjee and Shawn C. Shadden The Role Of Hemodynamics In Organizing Transport In Thrombus Neighborhood
P24 Sarah Basehore and Alisa Clyne Shear stress alters endothelial glucose metabolism
* P25 Ian Harding, Solomon Mensah, Ming Cheng, Ronodeep Mitra and Eno Ebong The Endothelial Glycocalyx Under Flow: An Important Factor in Endothelium Function
P26 Deborah Leckband, Arkaprava Dan, Xinyu Kong and Roberto Andresen-Eguiluz Adhesion Proteins and Growth Factor Receptors Coordinate to Regulate Endothelial Mechanotransduction
P27 Rosalyn Sayaman, Claire Robertson, Wen-Rong Lie, Amir Jaberi, Zheyun Xu, Mark Labarge and Mina Bissell Fibronectin disrupts normal breast myoepithelial function in basement membrane homeostasis and promotes alteration of laminin network microstructure
P28 Joseph O'Connor, Sandeep Nalluri, Paul Blanchard and Esther Gomez Biophysical regulation of epithelial-mesenchymal transition
P29 Joshua Morgan, Peter Sariano, Olivia Powell and Jason Gleghorn Leveraging embryonic development to generate a functional smooth muscle culture model
P30 Yanitza Rodriguez Studying the Cellular Mechanisms of Epilepsy: Characterization of Cerebral Organoids with PCDH19 Mutation
P31 Christopher Neal, Braden Stuart, Robert Tung and A.J. Mellott Culturing Human Wharton’s Jelly Cells in the Presence of Mechanical Tension as a Model of Cutaneous Wound Healing
P32 Evan Phillips, Brett Haislup, Joseph Sincavage, Katsiaryna Prudnikova, Mary Mulcahey, and Michele Marcolongo Diffusion of Biomimetic Proteoglycans Results in Cartilage Pericellular Augmentation:  A New Model to Explore Mechanotransduction
* P33 Matthew Fisher, Stephanie Cone and Paul Warren The Anterior Cruciate Ligament of the Knee: A Unique Model for Exploring the Impact of Mechanobiology at Multiple Scales During Post-Natal Growth
P34 Judith Piet, Roland Baron and Sandra Shefelbine Mechanobiology in the aging skeleton:  Can old bones respond to load?
* P35 Timothy Jacobsen, Paula Hernandez and Nadeen Chahine Actomyosin Contractility Mediates Multiscale Mechanobiology of the Intervertebral Disc in Pro-Inflammatory Environments
P36 Emily Moore, Yaxing Zhu, Han Seul Ryu and Christopher Jacobs Periosteal osteochondroprogenitors contribute to load-induced adult bone formation   through a primary cilium-mediated mechanism
P37 Brittany Jacobs and Kyle Allen Exercise Effects on Gait in a Rodent Model of Osteoarthritis
P38 Whasil Lee, Andrea Schwartz, Holly A. Leddy, Amy L. McNulty, Farshid Guilak and Wolfgang Liedtke Enhanced expression and function of the mechanosensitive ion channel Piezo1 in osteoarthritic chondrocytes
* P39 Ryan Mcdonough, Janty Shoga and Christopher Price DREADDs: A Tool for the Chemogenetic Manipulation of Chondrocyte Activity In Vitro
P40 Salma Mahzoon and Michael Detamore Bioactive Peptides for Designing Chondroinductive Biomaterials
P41 Abdolrasol Rahimi, Ryan Richter and Natasha Case Effects of Varying Low Intensity Ultrasound Parameters on Osteoblast Responses
P42 Michael Duffy, Mckenzie Sup and Christopher Jacobs Adenylyl cyclase 3 is differentially expressed in osteocyte primary cilia and contributes to mechanotransduction
P43 Brian Graham, Axel Moore, Margot Farnham, David Burris and Christopher Price The Role of Activity in Cartilage Function and Homeostasis: Implications for Joint Health
* P44 Johanna Farkas, James Monaghan and Sandra Shefelbine Exploring joint morphogenesis in regeneration of the axolotl salamander limb
P45 Lauren Resutek and Adam Hsieh Chordoma Cell Mechanosensitivity to Substrate Stiffness is Dependent on Vimentin Intermediate Filaments
P46 Andrew Tamashunas, Vincent Tocco, James Matthews, Hendrik Luesch, Jonathan Licht and Tanmay Lele Abnormal Nuclear Morphologies in Cancer: Role of Chromatin Regulators
P47 In Kyu Sung, Zhiyao Ma, Wai Ki Wong, Hon Chung Chau, Singwan Wong, Yifei Yao and Arthur Mak Intracellular Redox Status and Myoblast Viability Under Prolonged Compressive Loading
* P48 Joel Boerckel, Pinar Zorlutuna, Mervin Yoder and Devon Mason Cytoskeletal feedback control of mechanotransduction and cell motility by YAP/TAZ
* P49 Bo-Jian Lin, Shun-Hao Tsao and Grace Chao Lipid Rafts Sense and Direct Electric Field-induced Migration
P50 Yijia Pan, Linda Shi, Daryl Preece, Veronica Gomez-Godinez, Seung-Hynn Woo, Shaoying Lu, Shu Chien, Michael Berns and Yingxiao Wang Laser induced shockwave elicits the transient mode of the biomodal actions of mechanosensor Piezo1
P51 William Bachman and David Long Force Transmission and Morphological Variation in Populations of Endothelial Cell Clusters
P52 Mary Doolin and Kimberly Stroka Human Mesenchymal Stem Cell Nuclei Deform Anisotropically in Response to Mechanical Confinement
P53 Morgan Chabanon, James Cs Ho, Atul N Parikh and Padmini Rangamani Pulsatile Lipid Vesicles as a Model for Osmotically Activated Artificial Cells
P54 Rosa Kaviani, Chris Sitaras, Haruka Yoshie and Allen Ehrlicher Filamin A mechanosensing in shear stress
P55 Daniel Stewart, P. Nicole Serrano, Malcolm Maden and Chelsey S. Simmons Influences of Matrix Elasticity on Dermal Fibroblasts in Regenerative Mouse Model
P56 A.J. Mellott Breaking the Barrier to Mesenchymal Stem Cell Expansion Through a Novel 3D Expandable Scaffold
* P57 Xufeng Xue, Yubing Sun, Agnes Resto-Irizarry, Koh Meng Aw Yong, Yi Zheng, Yue Shao, Shinuo Weng and Jianping Fu Mechanically Guided Emergent Patterning of Neuroectoderm Tissue  Using Human Pluripotent Stem Cells
P58 Kerim Kaylan, Ian Berg and Gregory Underhill Notch signaling coordinates with cell contractility to regulate biliary differentiation of liver progenitor cells
P59 Arghya Paul Mechanobiologically-Activated Stem Cells for Cardiac Repair : in vitro and in vivo studies
P60 Hao Ma, Shengchang Tang, Po-Chiao Lin and Kristi Anseth Controlling differentiation of human mesenchymal stem cells in viscoelastic synthetic microenvironments
P61 Jennifer Soto, Szeyue Wong, Julia Chu and Song Li Role of Mechanotransducers in the Direct Conversion of Fibroblasts into Neurons
P62 Daniel Bowers and Justin Brown A Systems Mechanobiology Approach to Understand the Role of ECM Geometry on Stem Cell Differentiation
P63 Glendon Plumton, Alfonso Martin-Pena, Glyn Palmer, Adam Biedrzycki, Vrunda Trivedi and Blanka Sharma Hydrogels with Conditionally Active Reporters to Monitor Stem Cell Recruitment and Chondrogenesis
P64 Archana Singh and Prakriti Tayalia Semi-synthetic hydrogel matrices for studying differences in cell behavior in 2D and 3D microenvironment
P65 Omar Banda, Ryan Taitano and John Slater A Reference-Free Strain Measurement Platform for Mechanical Characterization of Hydrogels and Traction Force Microscopy
P66 Tolou Shokuhfar Nanotubes with Optimal Stiffness for Enhanced Mechano-response of Osteoblasts
P67 Shikhar Mehta, Rebecca Reals, Andrew Doyle, Snehasis Bhakta, Armin Vedadghavami and Ambika Bajpayee Co-targeting Multiple Joint Tissues with IL-1RA for Treatment of Osteoarthritis
P68 Muzhaozi Yuan, Ya Wang and Yi-Xian Qin Promotion of neuro-cell motility and regeneration by nerve growth factor coated superparamagnetic iron oxide-gold nanoparticle and triggered by dynamic magnetic field
P69 Weikun Xiao, Alireza Sohrabi, Yasmin Ghochani, Christopher Walthers, Arshia Ehsanipour, Rongyu Zhang, Songping Sun, Jesse Liang, Lisa Ta, Harley Kornblum, David Nathanson and Stephanie Seidlits Biomaterials Mimicking the Glioblastoma Microenvironment
P70 Moonhor Ree, Jin Chul Kim, Kyungho Kwon, Jongchan Lee and Hoyeol Lee Self-Assemblies of Organic Polymers and Their Biosensing Characteristics
P71 Michael Yaeger, Barbara Muller-Borer, Sky Reece, Brita Kilburg-Basnyat, Bin Lou, Mary Thomassen, Mike Fessler, Kimberly Kew, William Allen and Kymberly Gowdy Designing a Dysfunctional High Density Lipoprotein (D-HDL) Mimetic Peptide to Better Characterize D-HDL Function
* P72 Shengchang Tang, Hao Ma, Po-Chiao Lin and Kristi Anseth Developing novel viscoelastic hydrogels based on boronate esters for understanding cell-matrix interactions
P73 Shruti Salunkhe, Divya Bijukumar, Dalton Morris, Deborah Hall, Robin Pourzal and Mathew Mathew Experimental Evidence of Macrophages on Cell Induced Corrosion of CoCrMo alloy: Hip Implant Application
P74 N'Dea Irvin-Choy Bio Metamaterials for Orthopedics
P75 Daniel Chester, Rahul Kathard, Jeremy Nortey and Ashley Brown Colloidal Thin Films with Highly Controllable Viscoelastic Properties for Directing Cellular Responses
P76 David Medina Cruz and Thomas Webster Synthesis and Characterization of Biogenic Selenium Nanoparticles with Antimicrobial Properties Made by Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus (MRSA), Escherichia coli and Pseudomonas aeruginosa.
P77 Candice Sears, Eoin McNeill, Zach Richards, David Chimene, Nick Sears, Akhilesh Gaharwar, Carl Gregory and Roland Kaunas Nanoengineered Ionic-Covalent Entanglement (NICE) Bioink that Mimics the Osteogenic Niche for Craniomaxillofacial Implants
P78 Tracie Ferreira, Nicholas Macedo, Antonio Cabral and Jaqueline Tran Influencing Cell Membrane Potential with Electrotherapy to Promote Improved Wound Healing
P79 Anna Liu, Muhymin Islam, Nicholas Stone, Vikram Varadarajan, Jenny Jeong, Sam Bowie, Peng Qiu, Edmund Waller, Alexander Alexeev and Todd Sulchek Ultrafast microfluidic mechanical compression of cells for efficient intracellular delivery of large macromolecules
P80 Md Shamim Ahmmed and Siva Vanapalli Multidimensional High Throughput Mechanical Phenotyping of Cells
P81 Daniel Shiwarski, Joshua Tashman, Malachi Blundon, Brooke McCartney and Adam Feinberg Mapping 3D Mechanical Strains during Tissue Morphogenesis with a Novel Fibronectin-based Nanomechanical Biosensor
P82 Kai Wang, Jiafeng Liu and Yong Yang Understanding Nanotopographical Modulation of Cell Behavior
* P83 Eleanor Ory, Desu Chen, Kristi Chakrabarti, Keyata Thompson, Cornell Lee, Wolfgang Losert and Stuart Martin Microtentacle Features and Dynamics of Tumor Cells on Lipid Tethering Surfaces
P84 Katherine Young, Tom Bongiorno, John McDonald and Todd Sulchek Single Cell Genomechanics: New Method to Combine Mechanical and Gene Expression Data on Single Cell Level
P85 Heesoo Kim, Kyungho Kwon, Changsub Kim and Jongchan Lee A New Cell-Membrane Mimicking System and Its Biological Affinities
P86 Daniel Whitefield, Stephen Spagnol, Travis Armiger, Li Lan and Kris Dahl Quantifying DNA Damage Response in Transcriptionally Active vs Repressed Chromatin
* P87 Mizanur Rahman, Marton Toth, Taslim Anupom, Monica Driscoll and Siva Vanapalli Hammering worms and neural mechanobiology: Insights into traumatic brain injury
* P88 Travis Armiger, Marsha Lampi, Cynthia Reinhart-King and Kris Dahl Probing Epithelial Monolayers with Subnuclear Sensors of Cellular Forces
P89 James Carrow, Lauren Cross, Robert Reese, Manish Jaiswal, Carl Gregory, Roland Kaunas, Irtisha Singh and Akhilesh Gaharwar Whole-Transcriptome Analysis of Two-Dimensional Nanosilicates to Discern Pivotal Cellular Pathways
P090 Samantha Pellegrino and Christopher Norberg Cytotoxicity Analysis of Lipidic Ionic Liquids for Biomedical Applications

* Poster teaser presentations: Wednesday, January 3, 10:00am - 10:45am