New drug application could stop spread of brain cancer cells
A team of researchers at Virginia Tech, are developing a solution to stop the spreading of cancer cells due to interstitial fluid flow.In people who have glioblastoma, the deadliest form of brain cancer, this fluid has a much higher pressure, causing it to move fast and forcing cancer cells to spread, according to an article about the research. And a common cancer therapy, which inserts a drug directly into the tumor with a catheter, can make this fluid move even faster.
The Virginia Tech team, led by Jennifer Munson, an assistant professor in the Department of Biomedical Engineering and Mechanics in the College of Engineering, are working on the a solution to stop the cancer cell spread, according to the article. Munson is a BMES member.
In an article published on Nov. 19 in Scientific Reports, Chase Cornelison, lead author and a postdoctoral researcher at Virginia Tech, details the use of a drug that Munson's team found can block the way cancer cells respond to fluid flow. This work is part of a Munson-led five-year research grant project across multiple universities, examining the role of interstitial fluid flow in the spread of glioma cells, the article states. Interstitial fluid is the fluid that surrounds cells in the body.
The majority of this research happened at the University of Virginia, where Munson previously worked before she came to Virginia Tech in 2017.
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