U of Utah engineers develop method to 3-D print ligaments and tendons

A team of University of Utah biomedical engineers have developed a method to 3-D-print cells to produce human tissue such as ligaments and tendons, according to a university article.
A person with a damaged ligament, tendon, or ruptured disc could have new replacement tissue printed and ultimately implanted in the damaged area, according to the article. The research is expalined in a new paper published in the Journal of Tissue Engineering, Part C: Methods.

“It will allow patients to receive replacement tissues without additional surgeries and without having to harvest tissue from other sites, which has its own source of problems,” said University of Utah biomedical engineering assistant professor Robby Bowles in the article. Bowles co-authored the paper along with former U biomedical engineering master's student, David Ede. Bowles and Ede are BMES members.

The 3-D-printing method, which took two years to research, involves taking stem cells from the patient's own body fat and printing them on a layer of hydrogel to form a tendon or ligament which would later grow in vitro in a culture before being implanted, the article states. But it's an extremely complicated process because that kind of connective tissue is made up of different cells in complex patterns. For example, cells that make up the tendon or ligament must then gradually shift to bone cells so the tissue can attach to the bone.

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