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Wake Forest scientists use nanotechnology to detect molecular biomarker for osteoarthritis

Researchers at Wake Forest Baptist Medical Center have been able to measure a specific molecule related to osteoarthritis and a number of other inflammatory diseases using a newly developed technology, according to a university article
This preclinical study used a solid-state nanopore sensor as a tool for the analysis of hyaluronic acid (HA), according to the article.
 
 HA is a naturally occurring molecule that is involved in tissue hydration, inflammation and joint lubrication in the body, it states. The abundance and size distribution of HA in biological fluids is recognized as an indicator of inflammation, leading to osteoarthritis and other chronic inflammatory diseases. It can also serve as an indicator of how far the disease has progressed. 
 
“Our results established a new, quantitative method for the assessment of a significant molecular biomarker that bridges a gap in the conventional technology,” said lead author Adam R. Hall, Ph.D., assistant professor of biomedical engineering at Wake Forest School of Medicine, part of Wake Forest Baptist. Hall is a BMES member.
 
“The sensitivity, speed and small sample requirements of this approach make it attractive as the basis for a powerful analytic tool with distinct advantages over current assessment technologies.”

Read the full article HERE.
 

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