Northwestern and U of Chicago researchers successfully re-grow bone

A team of researchers repaired a hole in a mouse's skull by regrowing "quality bone," a breakthrough that could drastically improve the care of people who suffer severe trauma to the skull or face, according to a Northwestern University article.

The work by a joint team of Northwestern Engineering and University of Chicago researchers shows that a combination of technologies was able to regenerate the skull bone with supporting blood vessels in just the discrete area needed without developing scar tissue. The method was also more rapid than previous methods.

“The results are very exciting,” said BMES fellow Guillermo Ameer, professor of biomedical engineering at Northwestern's McCormick School of Engineering, and professor of surgery at Feinberg School of Medicine.

According to a paper published in PLOS One about the research, “Large skeletal defects caused by trauma, congenital malformations, and post-oncologic resections of the calvarium present major challenges to the reconstructive surgeon.”

The paper conluded: The combination of AdBMP-9 progenitor cell therapy and a PPCN-g microenvironment represents a promising and innovative approach to craniofacial defect repair.

CLICK HERE for the Northwestern article.
CLICK HERE for the PLOS One article.