Ohio State researchers develop regenerative medicine technology
Researchers at The Ohio State University Wexner Medical Center and Ohio State's College of Engineering have developed a new technology that can generate any cell type of interest for treatment within the patient's own body, according to a university article.The technology is called Tissue Nano-Transfection (TNT) and was developed by Daniel Gallego-Perez, assistant professor of biomedical engineering and surgery along with L. James Lee, professor of chemical and biomolecular engineering and Chandan K. Sen, director of Ohio State's Center for Regenerative Medicine & Cell Based Therapies, according to the article.
Their work was published in Nature Nanotechnology.
Applications for this technology could include localized reprogramming of tissues for regenerative medicine, or gene editing to correct abnormalities among others, according to the article. This technology may be used to repair injured tissue or restore function of aging tissue, including organs, blood vessels and nerve cells.
Researchers studied mice and pigs in these experiments. In the study, researchers were able to reprogram skin cells to become vascular cells in badly injured legs that lacked blood flow. Within one week, active blood vessels appeared in the injured leg, and by the second week, the leg was saved. In lab tests, this technology was also shown to reprogram skin cells in the live body into nerve cells that were injected into brain-injured mice to help them recover from stroke.