Yale research creates method to mimic stem cells, which could one day be used to treat the effects of a heart attack

Yale research project deciphers stem cell language, encoded by the various chemicals secreted by the cells.
Stem cell therapies have been hampered by possible side effects, which are frequently hard to predict, according to a Yale article.

One way around this hurdle is to understand how stem cells create their therapeutic effects, and then try to mimic them, according to the article

In a new study, Yale researchers succeeded in mimicking stem cells, opening the door to new stem cell-inspired, cell-free treatments for the effects of a heart attack, it states.

Led by the lab of Andre Levchenko, the John C. Malone Professor of Biomedical Engineering at Yale, a study published by the Proceedings of the National Academy of Sciences (PNAS) this week examined for the first time the dynamics of stem cell secretions in response to different stresses.

Levchenko is a BMES member.

Using a combination of microfluidics developed at Levchenko's lab and computer modeling, researchers created a platform to record the dynamic cocktail of stem cell secretions in depth, decoding the precise ways in which the words and messages of these cells are arranged as they provide a life-line to damaged heart cells. This analysis was revealing of the larger world of cell communication in our bodies.

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