Carnegie Mellon researchers developing methods to create a human lung

Carnegie Mellon University researchers are developing approaches to help people with lung disease by making them new ones.
Erica Comber, a Ph.D. student in the Department of Biomedical Engineering (BME), and her colleagues in Carnegie Mellon's Bioengineered Organs Initiative are working on the project, according to a university aricle.

Comber and her adviser Keith Cook, professor of biomedical engineering, recently outlined several different approaches to creating human lungs from scratch in a paper.

"There's a huge divergence of approaches in this field, and no one approach is necessarily more valid than another," Comber said in the article. "It's about using different techniques to try to accomplish the same goal and then learning from each other."

Cook is a BMES member.

By identifying important parameters to consider and describing different approaches, the paper, published in Translational Research, will act as a guide to future researchers looking to create human organs de novo, or "from scratch."

Approaches span from using existing biological organs as a starting point — by removing cells from existing organs and recellularizing them with the patient's own cells — to generating completely artificial organs.

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