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Real-time detection of cholesterol in liver-on-chip cultures of human liver cells

Researchers have developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes.
The innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time, according to a Science Daily announcement.

In a paper to be published in the September/December 2019 issue of TECHNOLOGY, a team of researchers from the Department of Biomedical Engineering at Illinois Institute of Technology, Chicago has developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes, according to the announcement.

BMES member Abhinav Bhushan is the principle investigator.

Their innovation lies not merely in the development of the first on-chip real-time assay for cholesterol detection but also in adapting the assay chemistry which is common in the conventional well-plate based enzymatic assay for cholesterol to microfluidic format and localizing it on the microscopic beads, it states. This innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time.

Read more HERE.