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Researchers Create 3D Model to Better Understand the Mitral Valve

In the current issue of Cellular and Molecular Bioengineering, BMES members at the University of Texas, Austin share their research create 3D model to better understand the mitral valve.
The article is titled: The Three-Dimensional Microenvironment of the Mitral Valve: Insights into the Effects of the Physiological Load.

The article is a result of experimental and computational research from Professor Michael Sacks' Willerson Center for Cardiovascular Modeling and Simulation. Sacks is a BMES member.

In a U of Texas article, BMES member Salma Ayoub, the paper's first author and 2018 doctoral graduate to learn more, talked about the team's research.

“The question that led to this paper started with Dr. Sacks asking us what the cells of the mitral valve sense and what surrounds them. In order to further tissue engineering in this field we need to know the answers to these questions,” Ayoub said in the article.

While some aspects of the mitral valve microenvironment have been studied, a detailed understanding of the three-dimensional structures was lacking due to constraints in microscopy modalities. To address this, Ayoub and the team used focused ion beam scanning electron microscopy (FIB-SEM) to reveal details of the mitral valve microenvironment at a much higher resolution than what would have been achievable through light or confocal microscopy, according to the article.

For the CMBE article CLICK HERE.

For the U of Texas article CLICK HERE.