Medical imaging technology detects vascular disorders, injuries in brain without invasive contrast agents
Purdue University researchers have developed an analytical imaging technology based on functional MRI for detecting and monitoring cerebral vascular disorders and injuries that does not require the use of contrast agents according to a university article.The new imaging method focuses on tracking an intrinsic blood-related MRI signal, which has been shown to travel with the blood, according to the article. The signal is used as a natural biomarker to assess blood flow in a patient.
“We can compare the signal from symmetric arteries and veins in both hemispheres or neck to assess the cerebrovascular integrity, or the balance of blood flow,” said Yunjie Tong, an assistant professor in Purdue's Weldon School of Biomedical Engineering, who developed the technology along with Blaise Frederick, a biophysicist and associate professor at Harvard Medical School. “The blood flow should be symmetric between the two sides in a healthy subject,” Tong said in the article. Tong is a BMES member
The time delay between the intrinsic signals from the internal carotid artery and the internal jugular vein represents the cerebral circulation time. A prolonged time delay also indicates blood flow disturbance in the brain, possibly caused by a tumor, traumatic brain injury or other brain disorders or diseases.
Traditional imaging methods, including MRIs, calculate the cerebral circulation time using contrast agents, which are injected into the patient. The measurement can only be made for a few seconds after the injection, but the new method will allow a continuous monitoring of the circulation time.
“The new method can even be applied on some existing MRI data to calculate the cerebral circulation time,” Tong said. “This method is safer and non-invasive since we don't inject contrast agents, which can stick to vessels or cause other health problems.”
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