U of Texas professor Jiang to develop new platform for cancer immune therapy
Jenny Jiang, assistant professor in the Department of Biomedical Engineering at the University of Texas, Austin, has received a new grant to develop an integrated platform that will identify T cell receptors to treat cancer.The grant is from the National Cancer Institute (NCI), a part of the National Institutes of Health (NIH). Jiang is a BMES member.
T cell receptor-based adoptive cell transfer therapy involves isolating cancer antigen specific T cell receptors, engineering them into patient derived T cells, and reinfusing these T cells back into patients to treat disease, according to a university article.
While recent successes have generated excitement in the research community, the lack of an efficient tool for isolating therapeutic T cell receptors has limited this approach.
Jiang's team will develop an integrated technology to speed up the process of therapeutic T cell receptor identification and validation. The research aims to establish a foundation for a paradigm shift in future cancer immune therapy, as well as make T cell receptor-based adoptive cell transfer therapy applicable to more kinds of cancers and more patients.