Schematic of a "biomimetic nano-scaffold" that combines novel nano-fibrous architecture of a interconnected pore network with micro or nano spheres for controlled release of regenerative factors. The design mimics collagen, offering a high surface area for cell attachment and new matrix deposition, and an open structure that encourages cell-cell, cell-nutrient, and cell-signal molecule interactions. The biological functional moieties (gold stars) enhance surface properties of the scaffold for tissue regeneration. The materials are biodegradable so that they will fade away after serving as a template.
Image courtesy Peter Ma

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